Dichloropane (RTI-111) (also known as RTI-111 or O-401) is a novel stimulant substance of the phenyltropane class. Its effects include stimulation, thought acceleration, appetite suppression and euphoria. It is structurally related to cocaine and shares many of its effects, although it notably lacks its local anesthetic properties.

Dichloropane has been shown to have a slower onset and longer duration of action compared to cocaine in animal studies. Anecdotal reports characterize it as having the basic stimulant qualities of cocaine but without as much euphoria, more protracted comedown, and less general enjoyability.

Dichloropane first appeared on the research chemical market around 2010. It is among to the first cocaine analog to be made available (in limited quantities) on the online research chemical market.

Very little is known about the pharmacology, metabolism, and toxicity of dichloropane. It is highly advised to use harm reduction practices if using this substance.

Dichloropane is a derivative of 3-phenyltropane. Methylecgonidine as the direct precursor to this compoun. It is produced as a hydrochloride salt in its powdered form.

Dichloropane is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring. The tropane ring of RTI-11 is substituted with a carbomethoxy group, also found in cocaine. RTI-111 differs from cocaine by its other addition, a dichlorinated phenyl ring. The phenyl ring of RTI-111 is substituted at R3 and R4 with chlorine groups. The phenyl ring of RTI-111 is attached directly to its tropane ring while in cocaine a carboxylate group bridges the two rings

The most extensively studied effect of dichloropane on the central nervous system is the blockade of the serotonin, dopamine, and norepinephrine transporter. This substance acts as a triple reuptake inhibitor and prevents monoamine neurotransmitters from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of monoaminergic signaling at receptors on the receiving neuron. It is this sudden flood of neurotransmitters in the synapses of various brain regions that is thought to cause dichloropane’s effects.

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